Gardner’s syndrome

Gardner’s syndrome is a genetic disorder characterized by the presence of multiple polyps in the colon together with tumors outside the colon. The extracolonic tumors may include osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas and sebaceous cysts. The countless polyps in the colon predispose to the development of colon cancer.

 

Gardner syndrome in an 80-year-old man. Panorex radiograph demonstrates multiple osteomas (arrows) throughout the mandible. Note the osteoma within the right maxilla (arrowhead).

Skull radiograph demonstrates multiple osteomas of the skull and mandible.

gardner syndrome

Upper gastrointestinal study with small bowel follow-through shows multiple polypoid filling defects involving the duodenum, jejunum, and ileum (arrows).

24-year-old man with Gardner’s syndrome who presented with abdominal pain. Axial T2-weighted MR image through abdomen shows mixed-signal-intensity mass (arrowheads) with prominent areas of low signal (arrows), believed to represent fibrosis. Percutaneous biopsy confirmed diagnosis of intraabdominal fibromatosis.

 

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