Peutz-Jegers syndrome (PJS) is a rare hereditary disease characterized bymelanocytic macules of the lips, gastrointestinal hamartomatous polyps andan increased risk for many classes of cancer. The serine/threonine kinase LKB1(also designated STK11) has been identified as the gene mutated in PJS. LKB1activity increases upon the binding of a regulatory complex consisting of theSte20-related adaptor α (STRAD α) pseudo kinase and the calcium-bindingprotein 39 (MO25 α).

 Zenker diverticulum. Lateral single-contrast esophagogram shows a large outpouching (*) arising from the region of the cricopharyngeus posterior to the normal esophagus (arrow).

Esophagus / Conventional Radiography / Barium esophagography / There is compression (black arrows) of the upper thoracic esophagus with associated ulceration (white arrow) due to caseating tuberculous nodes that have eroded into the esophagus
Tuberculous esophagitis.There is compression (black arrows) of the upper thoracic esophagus with associated ulceration (white arrow) due to caseating tuberculous nodes that have eroded into the esophagus. (Courtesy of Alan Grundy, MD, London, England.)

1. Esophagus / Fluoroscopy / Barium swallow / Elderly Adult / Male / Less severe simultaneous nonperistaltic contractions
Nonperistaltic contractions in the esophagus. Another elderly man without esophageal symptoms has less severe simultaneous nonperistaltic contractions. (From Ott DJ: Radiologic evaluation of esophageal dysphagia. Curr Probl Diagn Radiol 17:1-33, 1988.)