Peutz-Jegers syndrome (PJS)

Peutz-Jegers syndrome (PJS) is a rare hereditary disease characterized bymelanocytic macules of the lips, gastrointestinal hamartomatous polyps andan increased risk for many classes of cancer. The serine/threonine kinase LKB1(also designated STK11) has been identified as the gene mutated in PJS. LKB1activity increases upon the binding of a regulatory complex consisting of theSte20-related adaptor α (STRAD […]
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