Fibrous dysplasia of bone

Fibrous dysplasia is a disease that causes bone thinning and growths or lesions in one or more bones, and leads to bone weakness and scar formation within the bones.
Fibrous dysplasia is very rare; not much is known about it, and there is no known cure. Levels of the transcription factor C-fos are raised in fibrous dysplasia, leading to gene over-expression and tumour formation. It is not hereditary. There are two types of fibrous dysplasia:
Monostotic (Involving a single bone, or adjecent bones, like both the upper and lower jaw)
Polyostotic (Involving many bones).


The most severe form of polyostotic fibrous dysplasia is known as McCune-Albright syndrome.
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